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    J Cardiothorac Anesth. 1990 Aug;4(4):469-73.

    Low-dose dopamine during cardiopulmonary bypass in patients with renal dysfunction.

    Costa P, Ottino GM, Matani A, Pansini S, Canavese C, Passerini G, Grezzana G.

    Source

    Department of Cardiac Surgery, University of Torino, Italy.

    Abstract

    Thirty-six patients with preoperative renal dysfunction were studied to evaluate the effects of dopamine (D) and dopamine-nitroprusside (DN) on renal function during cardiopulmonary bypass (CPB). No differences from the control group (C) were found in creatinine clearance, fractional sodium excretion, osmolarity and free-water clearance. Sodium output/intake ratio during CPB was higher in group D than in groups C and DN (P less than 0.05); water output/intake ratio was higher in group D than in group C (P less than 0.05). Urine lysozime levels and alpha-glycosidase/creatinine ratios increased similarly in the three groups, suggesting ischemic tubular cell damage. No patients showed acute postoperative renal failure or a worsening of their renal dysfunction. The data suggest an increased water and sodium excretion during CPB with a dopamine infusion, possibly resulting from a renal vasodilator effect that was abolished by simultaneous nitroprusside administration.

    PMID:
    2132343
    [PubMed - indexed for MEDLINE]

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