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    Proc Natl Acad Sci U S A. 1990 Dec;87(24):9923-7.

    Mutation in a heterochromatin-specific chromosomal protein is associated with suppression of position-effect variegation in Drosophila melanogaster.

    Eissenberg JC, James TC, Foster-Hartnett DM, Hartnett T, Ngan V, Elgin SC.

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    E. A. Doisy Department of Biochemistry and Molecular Biology, St. Louis University School of Medicine, MO 63104.

    Abstract

    We report here that a point mutation in the gene which encodes the heterochromatin-specific nonhistone chromosomal protein HP-1 in Drosophila melanogaster is associated with dominant suppression of position-effect variegation. The mutation, a G-to-A transition at the first nucleotide of the last intron, causes missplicing of the HP-1 mRNA. This suggests that heterochromatin-specific proteins play a central role in the gene suppression associated with heterochromatic position effects.

    PMID:
    2124708
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC55286
    Free PMC Article

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