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    Science. 1990 Oct 26;250(4980):533-8.

    Biophysical and molecular mechanisms of Shaker potassium channel inactivation.

    Hoshi T, Zagotta WN, Aldrich RW.

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    Department of Molecular and Cellular Physiology, Stanford University, School of Medicine, CA 94305.

    Abstract

    The potassium channels encoded by the Drosophila Shaker gene activate and inactivate rapidly when the membrane potential becomes more positive. Site-directed mutagenesis and single-channel patch-clamp recording were used to explore the molecular transitions that underlie inactivation in Shaker potassium channels expressed in Xenopus oocytes. A region near the amino terminus with an important role in inactivation has now been identified. The results suggest a model where this region forms a cytoplasmic domain that interacts with the open channel to cause inactivation.

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    PMID:
    2122519
    [PubMed - indexed for MEDLINE]

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