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    J Phys Chem C Nanomater Interfaces. 2010 Jan 1;1(20):3141-3146.

    Influence of Gold Nanoshell on Hyperthermia of Super Paramagnetic Iron Oxide Nanoparticles (SPIONs).

    Mohammad F, Balaji G, Weber A, Uppu RM, Kumar CS.

    Source

    Center for Advanced Microstructures & Devices, Louisiana State University, 6980 Jefferson Highway, Baton Rouge, LA 70806. USA.

    Abstract

    Gold nanoshell around super paramagnetic iron oxide nanoparticles (SPIONs) was synthesized and small angle X-ray scattering (SAXS) analysis suggests a gold coating of approximately 0.4 to 0.5 nm thickness. On application of low frequency oscillating magnetic fields (44 - 430 Hz), a four- to five-fold increase in the amount of heat released with gold-coated SPIONs (6.3 nm size) in comparison with SPIONs (5.4 nm size) was observed. Details of the influence of frequencies of oscillating magnetic field, concentration and solvent on heat generation are presented. We also show that, in the absence of oscillating magnetic field, both SPIONs and SPIONs@Au are not particularly cytotoxic to mammalian cells (MCF-7 breast carcinoma cells and H9c2 cardiomyoblasts) in culture, as indicated by the reduction of 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium by viable cells in a phenazine methosulfate-assisted reaction.

    PMID:
    21103390
    [PubMed]
    PMCID:
    PMC2987684
    Free PMC Article

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