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    Science. 1990 Feb 16;247(4944):836-8.

    Activin-binding protein from rat ovary is follistatin.

    Nakamura T, Takio K, Eto Y, Shibai H, Titani K, Sugino H.

    Source

    Frontier Research Program, Institute of Physical and Chemical Research (RIKEN), Saitama, Japan.

    Abstract

    Activin, a member of the transforming growth factor beta protein family, was originally isolated from gonadal fluids and stimulates the release of pituitary follicle-stimulating hormone (FSH). Activin has numerous functions in both normal and neoplastic cells. Various cells synthesize activin and have a specific binding site for this peptide. However, the molecular basis for its actions is unknown. A binding protein for activin was purified from rat ovary and was identical to follistatin, a specific inhibitor of FSH release. It is likely that the binding protein participates in the diverse regulatory actions of activin.

    PMID:
    2106159
    [PubMed - indexed for MEDLINE]

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