Int J Tissue React. 1990;12(5):263-8.

In-vitro preparation of experimental models of hepatitis with D-galactosamine and their modification by liver-repairing factors.

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Division of Agricultural Chemistry, Faculty of Agriculture, Meiji University, Kanagawa, Japan.

Abstract

Hepatocytes, isolated from male F344/DuCrj rats by means of perfusion with collagenase, were incubated in Williams E medium containing newborn calf serum (PFCS), insulin, dexamethasone and D-galactosamine. The resulting liver-cell damage was confirmed by MTT assay to be dependent on the dose of D-galactosamine. This damage was clearly modified by the addition to the medium of the liver-repairing factors which appeared in serum in the initial stage of liver damage resulting from either partial hepatectomy or administration of D-galactosamine (Gal-N) in rats. When a massive number of splenocytes from normal rats was injected into the caudal vein of rats with liver damage caused by D-galactosamine, liver-damage-repairing factors were induced in the serum which were found to exert a particularly strong inhibition of the damage to hepatocytes caused by D-galactosamine when incubated in vitro.

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