J Rheumatol. 1990 Dec;17(12):1620-2.

Onset of symptoms of rheumatoid arthritis in relation to age, sex and menopausal transition.

Goemaere S, Ackerman C, Goethals K, De Keyser F, Van der Straeten C, Verbruggen G, Mielants H, Veys EM.

Source

Department of Rheumatology, Ghent University Hospital, Belgium.

Abstract

In a population of 564 patients with rheumatoid arthritis (RA), the onset of symptoms has been studied in relation to age, sex and last menstrual period for women. Median age of menopause was 49 years (3rd percentile: 32 years and 97th percentile: 56 years). Median age of first symptoms was 45 years in women and 50 in men. The individual interval between menopause and first symptoms has a Gaussian distribution with mean at time 0, implying that the average woman develops the first symptoms at the time of her menopause. The F:M ratio of all patients was 2.3; with increasing age the F:M ratio decreased from 3.7 before 30 years of age to 1 after the 6th decade of life, with a peak at the age of 40-44 years. A possible effect of age related changes in sex hormone levels on the pathogenesis of RA is suggested.

PMID:: 2084234; [PubMed - indexed for MEDLINE]

MeSH Terms, Substances

MeSH Terms

Substances

Gonadal Steroid Hormones

LinkOut - more resources

Medical

Libraries

LinkOut Holdings

Supplemental Content

Related citations

Adrenal and gonadal steroid hormone deficiency in the pathogenesis of rheumatoid arthritis. [J Rheumatol Suppl. 1996]
Adrenal and gonadal steroid hormone deficiency in the pathogenesis of rheumatoid arthritis.
Wilder RL. J Rheumatol Suppl. 1996 Mar; 44:10-2.
Sex and thyroid hormone status in women with rheumatoid arthritis: are there any effects of menopausal state and disease activity on these hormones? [Int J Clin Pract. 2004]
Sex and thyroid hormone status in women with rheumatoid arthritis: are there any effects of menopausal state and disease activity on these hormones?
Cevik R, Em S, Gur A, Nas K, Sarac AJ, Colpan L. Int J Clin Pract. 2004 Apr; 58(4):327-32.
Review Sex hormones and headache. [Rev Neurol (Paris). 2000]
Review Sex hormones and headache.
Silberstein SD. Rev Neurol (Paris). 2000; 156 Suppl 4:4S30-41.
Influence of sex, age, and menopausal state on the course of early rheumatoid arthritis. [J Rheumatol. 2001]
Influence of sex, age, and menopausal state on the course of early rheumatoid arthritis.
Kuiper S, van Gestel AM, Swinkels HL, de Boo TM, da Silva JA, van Riel PL. J Rheumatol. 2001 Aug; 28(8):1809-16.
Review The effects of gender and sex hormones on outcome in rheumatoid arthritis. [Baillieres Clin Rheumatol. 1992]
Review The effects of gender and sex hormones on outcome in rheumatoid arthritis.
Da Silva JA, Hall GM. Baillieres Clin Rheumatol. 1992 Feb; 6(1):196-219.

See reviews... See all...

Cited by 11 PubMed Central articles

Bone mineral density by digital X-ray radiogrammetry is strongly decreased and associated with joint destruction in long-standing rheumatoid arthritis: a cross-sectional study. [BMC Musculoskelet Disord. 2011]
Bone mineral density by digital X-ray radiogrammetry is strongly decreased and associated with joint destruction in long-standing rheumatoid arthritis: a cross-sectional study.
Forsblad-d'Elia H, Carlsten H. BMC Musculoskelet Disord. 2011 Oct 24; 12:242. Epub 2011 Oct 24.
Combined treatment with dexamethasone and raloxifene totally abrogates osteoporosis and joint destruction in experimental postmenopausal arthritis. [Arthritis Res Ther. 2011]
Combined treatment with dexamethasone and raloxifene totally abrogates osteoporosis and joint destruction in experimental postmenopausal arthritis.
Islander U, Jochems C, Stubelius A, Andersson A, Lagerquist MK, Ohlsson C, Carlsten H. Arthritis Res Ther. 2011 Jun 20; 13(3):R96. Epub 2011 Jun 20.
Women's experiences of sexual health when living with rheumatoid arthritis--an explorative qualitative study. [BMC Musculoskelet Disord. 2010]
Women's experiences of sexual health when living with rheumatoid arthritis--an explorative qualitative study.
Josefsson KA, Gard G. BMC Musculoskelet Disord. 2010 Oct 15; 11:240. Epub 2010 Oct 15.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Onset of symptoms of rheumatoid arthritis in relation to age, sex and menopausal...
Onset of symptoms of rheumatoid arthritis in relation to age, sex and menopausal transition.
J Rheumatol. 1990 Dec ;17(12):1620-2.

PubMed
Assessment of the potential pathogenicity of type II collagen autoantibodies in ...
Assessment of the potential pathogenicity of type II collagen autoantibodies in patients with rheumatoid arthritis. Evidence of restricted IgG3 subclass expression and activation of complement C5 to C5a.
Arthritis Rheum. 1986 Nov ;29(11):1316-21.

PubMed
Long-term second-line treatment: a prospective drug survival study.
Long-term second-line treatment: a prospective drug survival study.
Br J Rheumatol. 1992 Apr ;31(4):253-8.

PubMed
A randomized trial comparing aerobic exercise and resistance exercise with a hea...
A randomized trial comparing aerobic exercise and resistance exercise with a health education program in older adults with knee osteoarthritis. The Fitness Arthritis and Seniors Trial (FAST).
JAMA. 1997 Jan 1 ;277(1):25-31.

PubMed
Crystal-induced endogenous pyrogen production. A further look at gouty inflammat...
Crystal-induced endogenous pyrogen production. A further look at gouty inflammation.
Arthritis Rheum. 1985 Sep ;28(9):1039-46.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to: