Arthritis Res Ther. 2010;12(4):138. Epub 2010 Aug 26.

A new tool for detection of type I interferon activation in systemic lupus erythematosus.

Abstract

The IFN-I pathway is activated in systemic lupus erythematosus (SLE) and appears to be important in the pathogenesis of the disease. As a result, several clinical trials of anti-IFN monoclonal antibodies, which hold promise to control the disease, have been launched. Additionally, activation of IFN-I might be important in the prognosis and activity assessment of the disease. Therefore, new biomarkers that reflect activity of the IFN-I pathway and are simple to measure, such as the monocyte CD64 receptor, are expected to have a great impact on the management of SLE, if properly validated.

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Arthritis Res Ther. 2010;12(3):R90.

PMID:: 20815919; [PubMed - indexed for MEDLINE]
PMCID:: PMC2945060

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Monocyte surface expression of Fcgamma receptor RI (CD64), a biomarker reflecting type-I interferon levels in systemic lupus erythematosus. [Arthritis Res Ther. 2010]
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