Histopathology. 1990 Dec;17(6):489-503.

Monoclonal antibody Ki-67: its use in histopathology.

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Nuffield Department of Pathology, John Radcliffe Hospital, Oxford, UK.

Abstract

Monoclonal antibody Ki-67 is a reliable and easy means of accurately assessing the growth fraction of human neoplasms. Although the number of long-term follow-up studies is limited, it does appear to provide valuable prognostic information particularly in lymphoproliferative disease. Since the estimation of growth fraction is only one factor influencing tumour behaviour it would be naive to believe that measurement of this parameter alone, no matter how accurately, would provide the clinician with definitive prognostic information for all tumours. The antibody is also of use in research, providing a means of measuring proliferative activity in a variety of conditions besides malignancy, and may prove of value in monitoring tumour response to established and trial therapies.

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Review [In situ determination of the Ki-67 growth fraction (Ki-67 GF) in human tumors (studies in breast cancer)]. [Acta Histochem Suppl. 1990]
Review [In situ determination of the Ki-67 growth fraction (Ki-67 GF) in human tumors (studies in breast cancer)].
Lellé RJ. Acta Histochem Suppl. 1990; 39:109-24.
Cell proliferation of breast cancer evaluated by anti-BrdU and anti-Ki-67 antibodies: its prognostic value on short-term recurrences. [Eur J Cancer. 1993]
Cell proliferation of breast cancer evaluated by anti-BrdU and anti-Ki-67 antibodies: its prognostic value on short-term recurrences.
Gaglia P, Bernardi A, Venesio T, Caldarola B, Lauro D, Cappa AP, Calderini P, Liscia DS. Eur J Cancer. 1993; 29A(11):1509-13.
Ki-67 labeling index is a more reliable measure of solid tumor proliferative activity than tritiated thymidine labeling. [Am J Clin Pathol. 1990]
Ki-67 labeling index is a more reliable measure of solid tumor proliferative activity than tritiated thymidine labeling.
Deshmukh P, Ramsey L, Garewal HS. Am J Clin Pathol. 1990 Aug; 94(2):192-5.
Nuclear distribution of the Ki-67 antigen during the cell cycle: comparison with growth fraction in human breast cancer cells. [Cancer Res. 1989]
Nuclear distribution of the Ki-67 antigen during the cell cycle: comparison with growth fraction in human breast cancer cells.
van Dierendonck JH, Keijzer R, van de Velde CJ, Cornelisse CJ. Cancer Res. 1989 Jun 1; 49(11):2999-3006.
Review Ki-67 and other proliferation markers useful for immunohistological diagnostic and prognostic evaluations in human malignancies. [Semin Cancer Biol. 1990]
Review Ki-67 and other proliferation markers useful for immunohistological diagnostic and prognostic evaluations in human malignancies.
Gerdes J. Semin Cancer Biol. 1990 Jun; 1(3):199-206.

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