Chem Pharm Bull (Tokyo). 1990 Oct;38(10):2859-61.

Studies on absorption, distribution, excretion and metabolism of ginseng saponins. V. The decomposition products of ginsenoside Rb2 in the large intestine of rats.

Karikura M, Miyase T, Tanizawa H, Takino Y, Taniyama T, Hayashi T.

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School of Pharmaceutical Sciences, University of Shizuoka, Japan.

Abstract

The decomposition of ginsenoside Rb2 (Rb2) in the rat large intestine after oral administration was investigated in detail. A part of Rb2 was decomposed and six decomposition products (I-VI) were observed on thin-layer chromatogram. Among them, five products (I-V) were isolated, and identification of these compounds was done by carbon-13 nuclear magnetic resonance (13C-NMR). On the basis of 13C-NMR analysis, these compounds were identified as ginsenoside Rd (I), 3-O-beta-D-glucopyranosyl-20-O- [alpha-L-arabinopyranosyl(1----6)-beta-D-glucopyranosyl]-20(S)- proto-panaxadiol (II), ginsenoside F2 (III), 20-O-[alpha-L-arabinopyranosyl(1----6)-beta-D-glucopyranosyl]-20(S )- protopanaxadiol (IV), and compound K (V), respectively.

PMID:: 2076572; [PubMed - indexed for MEDLINE]

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Studies on absorption, distribution, excretion and metabolism of ginseng saponins. VII. Comparison of the decomposition modes of ginsenoside-Rb1 and -Rb2 in the digestive tract of rats. [Chem Pharm Bull (Tokyo). 1991]
Studies on absorption, distribution, excretion and metabolism of ginseng saponins. VII. Comparison of the decomposition modes of ginsenoside-Rb1 and -Rb2 in the digestive tract of rats.
Karikura M, Miyase T, Tanizawa H, Taniyama T, Takino Y. Chem Pharm Bull (Tokyo). 1991 Sep; 39(9):2357-61.
Studies on absorption, distribution, excretion and metabolism of ginseng saponins. VI. The decomposition products of ginsenoside Rb2 in the stomach of rats. [Chem Pharm Bull (Tokyo). 1991]
Studies on absorption, distribution, excretion and metabolism of ginseng saponins. VI. The decomposition products of ginsenoside Rb2 in the stomach of rats.
Karikura M, Miyase T, Tanizawa H, Taniyama T, Takino Y. Chem Pharm Bull (Tokyo). 1991 Feb; 39(2):400-4.
Studies on absorption, distribution, excretion and metabolism of ginseng saponins. VIII. Isotope labeling of ginsenoside Rb2. [Chem Pharm Bull (Tokyo). 1992]
Studies on absorption, distribution, excretion and metabolism of ginseng saponins. VIII. Isotope labeling of ginsenoside Rb2.
Karikura M, Tanizawa H, Hirata T, Miyase T, Takino Y. Chem Pharm Bull (Tokyo). 1992 Sep; 40(9):2458-60.
Review [Studies on the pharmacodynamics of ginsenoside-Rg1, -Rb1 and -Rb2 in rats]. [Yakugaku Zasshi. 1994]
Review [Studies on the pharmacodynamics of ginsenoside-Rg1, -Rb1 and -Rb2 in rats].
Takino Y. Yakugaku Zasshi. 1994 Aug; 114(8):550-64.
Review [Advances in the study of ginsenoside compound K]. [Yao Xue Xue Bao. 2007]
Review [Advances in the study of ginsenoside compound K].
Zhou W, Zhou P. Yao Xue Xue Bao. 2007 Sep; 42(9):917-23.

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Cited by 1 PubMed Central article

Pharmacology of ginsenosides: a literature review. [Chin Med. 2010]
Pharmacology of ginsenosides: a literature review.
Leung KW, Wong AS. Chin Med. 2010 Jun 11; 5:20. Epub 2010 Jun 11.

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