Stem Cell Res Ther. 2010 Jul 23;1(3):21.

Controlling the direction of division.

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Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, 10461 New York, USA. satir@aecom.yu.edu.

Abstract

Quyn and colleagues report that gut stem cells have a biased spindle orientation and asymmetric retention of label-retaining DNA. These features are lost in mouse and human tissues when the microtubule binding protein Apc is mutated. In the developing kidney, Apc acts downstream from primary cilium signaling to influence spindle orientation when noncanonical Wnt signaling predominates. Do gut stem cells also have primary cilia?

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PMCID: PMC2941113

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Controlling the direction of division.

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