Am J Pathol. 1991 Jun;138(6):1315-9.

Interleukin-4 induces the synthesis and secretion of MCP-1/JE by human endothelial cells.

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Division of Medicine, Dana-Farber Cancer Institute, Boston, MA 02115.

Abstract

The authors have demonstrated that human interleukin-4 (IL-4) induces increased expression of the mRNA encoding the monocyte-specific chemoattractant and activator, MCP-1/JE, in human endothelial cells (EC). In addition, treatment of ECs with IL-4 resulted in the synthesis and secretion of MCP-1/JE protein. While IL-4 did not significantly influence the induced expression of MCP-1/JE mRNA by interleukin-1 (IL-1) or tumor necrosis factor, concomitant treatment with IL-4 and IL-1 caused more secretion of MCP-1/JE protein than either cytokine alone. These results suggest that EC-produced MCP-1/JE may mediate some of IL-4's effects on monocyte physiology in vivo, including IL-4's anti-tumor properties.

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PMCID:: PMC1886397

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