Biol Direct. 2010 May 24;5:37.

Genome factor and gene pleiotropy hypotheses in protein evolution.

Source

School of Life Sciences, Fudan University, Shanghai 200433, China.

Abstract

The debate of genomic correlations between sequence conservation, protein connectivity, gene essentiality and gene expression, has generated a number of new hypotheses that are challenging the classical framework of molecular evolution. For instance, the translational selection hypothesis claims that the determination of the rate of protein evolution is the protein stability to avoid the misfolding toxicity. In this short article, we propose that gene pleiotropy, the capacity for affecting multiple phenotypes, may play a vital role in molecular evolution. We discuss several approaches to testing this hypothesis.

PMID:: 20497565; [PubMed - indexed for MEDLINE]
PMCID:: PMC2889903

Free PMC Article

Images from this publication.See all images (1) Free text

MeSH Terms, Substances

MeSH Terms

Substances

Proteins

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Libraries

LinkOut Holdings

Supplemental Content

Save items

Related citations in PubMed

Evolutionary framework for protein sequence evolution and gene pleiotropy. [Genetics. 2007]
Evolutionary framework for protein sequence evolution and gene pleiotropy.
Gu X. Genetics. 2007 Apr; 175(4):1813-22. Epub 2007 Feb 4.
A preliminary analysis of gene pleiotropy estimated from protein sequences. [J Exp Zool B Mol Dev Evol. 2010]
A preliminary analysis of gene pleiotropy estimated from protein sequences.
Su Z, Zeng Y, Gu X. J Exp Zool B Mol Dev Evol. 2010 Mar 15; 314(2):115-22.
Review Evolutionary systems biology: links between gene evolution and function. [Curr Opin Biotechnol. 2006]
Review Evolutionary systems biology: links between gene evolution and function.
Koonin EV, Wolf YI. Curr Opin Biotechnol. 2006 Oct; 17(5):481-7. Epub 2006 Sep 8.
Comparable contributions of structural-functional constraints and expression level to the rate of protein sequence evolution. [Biol Direct. 2008]
Comparable contributions of structural-functional constraints and expression level to the rate of protein sequence evolution.
Wolf MY, Wolf YI, Koonin EV. Biol Direct. 2008 Oct 7; 3:40. Epub 2008 Oct 7.
Review Why proteins evolve at different rates: the functional hypothesis versus the mistranslation-induced protein misfolding hypothesis. [FEBS Lett. 2009]
Review Why proteins evolve at different rates: the functional hypothesis versus the mistranslation-induced protein misfolding hypothesis.
Park D, Choi SS. FEBS Lett. 2009 Apr 2; 583(7):1053-9. Epub 2009 Feb 28.

See reviews... See all...

Cited by 2 PubMed Central articles

Sequence variability of Rhizobiales orthologs and relationship with physico-chemical characteristics of proteins. [Biol Direct. 2011]
Sequence variability of Rhizobiales orthologs and relationship with physico-chemical characteristics of proteins.
Peralta H, Guerrero G, Aguilar A, Mora J. Biol Direct. 2011 Oct 4; 6:48. Epub 2011 Oct 4.
The impact of multifunctional genes on "guilt by association" analysis. [PLoS One. 2011]
The impact of multifunctional genes on "guilt by association" analysis.
Gillis J, Pavlidis P. PLoS One. 2011 Feb 18; 6(2):e17258. Epub 2011 Feb 18.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Genome factor and gene pleiotropy hypotheses in protein evolution.
Genome factor and gene pleiotropy hypotheses in protein evolution.
Biol Direct. 2010 May 24 ;5:37.

PubMed
Mutator phenotype may be required for multistage carcinogenesis.
Mutator phenotype may be required for multistage carcinogenesis.
Cancer Res. 1991 Jun 15 ;51(12):3075-9.

PubMed
MicroRNAs in neuronal development, function and dysfunction.
MicroRNAs in neuronal development, function and dysfunction.
Brain Res. 2010 Jun 18 ;1338:3-13. Epub 2010 Apr 7 .

PubMed
The POL1 gene from the fission yeast, Schizosaccharomyces pombe, shows conserved...
The POL1 gene from the fission yeast, Schizosaccharomyces pombe, shows conserved amino acid blocks specific for eukaryotic DNA polymerases alpha.
Mol Gen Genet. 1991 Apr ;226(1-2):182-9.

PubMed
Phylogenomics of sterol synthesis: insights into the origin, evolution, and dive...
Phylogenomics of sterol synthesis: insights into the origin, evolution, and diversity of a key eukaryotic feature.
Genome Biol Evol. 2009 Sep 10 ;1:364-81.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: