Science. 1991 Jun 21;252(5013):1668-75.

Toward a science of metabolic engineering.

Source

California Institute of Technology, Pasadena 91125.

Abstract

Application of recombinant DNA methods to restructure metabolic networks can improve production of metabolite and protein products by altering pathway distributions and rates. Recruitment of heterologous proteins enables extension of existing pathways to obtain new chemical products, alter posttranslational protein processing, and degrade recalcitrant wastes. Although some of the experimental and mathematical tools required for rational metabolic engineering are available, complex cellular responses to genetic perturbations can complicate predictive design.

PMID:: 2047876; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Molecular Biology Databases

OXYGEN - HSDB

Libraries

LinkOut Holdings

Supplemental Content

Save items

Related citations in PubMed

Review Use of genome-scale microbial models for metabolic engineering. [Curr Opin Biotechnol. 2004]
Review Use of genome-scale microbial models for metabolic engineering.
Patil KR, Akesson M, Nielsen J. Curr Opin Biotechnol. 2004 Feb; 15(1):64-9.
Review Metabolic engineering of Escherichia coli and Corynebacterium glutamicum for biotechnological production of organic acids and amino acids. [Curr Opin Microbiol. 2006]
Review Metabolic engineering of Escherichia coli and Corynebacterium glutamicum for biotechnological production of organic acids and amino acids.
Wendisch VF, Bott M, Eikmanns BJ. Curr Opin Microbiol. 2006 Jun; 9(3):268-74. Epub 2006 Apr 17.
Metabolic genomics. [Adv Microb Physiol. 2005]
Metabolic genomics.
Chang DE, Conway T. Adv Microb Physiol. 2005; 50:1-39.
Review Engineering primary metabolic pathways of industrial micro-organisms. [J Biotechnol. 2007]
Review Engineering primary metabolic pathways of industrial micro-organisms.
Kern A, Tilley E, Hunter IS, Legisa M, Glieder A. J Biotechnol. 2007 Mar 30; 129(1):6-29. Epub 2006 Dec 2.
Review Metabolic engineering of microorganisms: general strategies and drug production. [Drug Discov Today. 2009]
Review Metabolic engineering of microorganisms: general strategies and drug production.
Lee SY, Kim HU, Park JH, Park JM, Kim TY. Drug Discov Today. 2009 Jan; 14(1-2):78-88. Epub 2008 Sep 18.

See reviews... See all...

Cited by 65 PubMed Central articles

Multi-objective optimization of enzyme manipulations in metabolic networks considering resilience effects. [BMC Syst Biol. 2011]
Multi-objective optimization of enzyme manipulations in metabolic networks considering resilience effects.
Wu WH, Wang FS, Chang MS. BMC Syst Biol. 2011 Sep 19; 5:145. Epub 2011 Sep 19.
An improved kinetic model for the acetone-butanol-ethanol pathway of Clostridium acetobutylicum and model-based perturbation analysis. [BMC Syst Biol. 2011]
An improved kinetic model for the acetone-butanol-ethanol pathway of Clostridium acetobutylicum and model-based perturbation analysis.
Li RD, Li YY, Lu LY, Ren C, Li YX, Liu L. BMC Syst Biol. 2011 Jun 20; 5 Suppl 1:S12. Epub 2011 Jun 20.
Statistics-based model for prediction of chemical biosynthesis yield from Saccharomyces cerevisiae. [Microb Cell Fact. 2011]
Statistics-based model for prediction of chemical biosynthesis yield from Saccharomyces cerevisiae.
Varman AM, Xiao Y, Leonard E, Tang YJ. Microb Cell Fact. 2011 Jun 21; 10:45. Epub 2011 Jun 21.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

Toward a science of metabolic engineering.
Toward a science of metabolic engineering.
Science. 1991 Jun 21 ;252(5013):1668-75.

PubMed
Binary image representation of a ligand binding site: its application to efficie...
Binary image representation of a ligand binding site: its application to efficient sampling of a conformational ensemble.
BMC Bioinformatics. 2010 May 18 ;11:256.

PubMed
Aggressive behavior in cognitively impaired nursing home residents.
Aggressive behavior in cognitively impaired nursing home residents.
Res Nurs Health. 1991 Apr ;14(2):87-95.

PubMed
Exploring the brain network: a review on resting-state fMRI functional connectiv...
Exploring the brain network: a review on resting-state fMRI functional connectivity.
Eur Neuropsychopharmacol. 2010 Aug ;20(8):519-34. Epub 2010 May 14 .

PubMed
Vitamin B6 is effective therapy for nausea and vomiting of pregnancy: a randomiz...
Vitamin B6 is effective therapy for nausea and vomiting of pregnancy: a randomized, double-blind placebo-controlled study.
Obstet Gynecol. 1991 Jul ;78(1):33-6.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: