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    Biol Direct. 2010 Apr 20;5:19; discussion 19.

    Cancer models, genomic instability and somatic cellular Darwinian evolution.

    Little MP.

    Source

    Department of Epidemiology and Biostatistics, School of Public Health, Imperial College Faculty of Medicine, London, UK. mark.little@imperial.ac.uk

    Abstract

    The biology of cancer is critically reviewed and evidence adduced that its development can be modelled as a somatic cellular Darwinian evolutionary process. The evidence for involvement of genomic instability (GI) is also reviewed. A variety of quasi-mechanistic models of carcinogenesis are reviewed, all based on this somatic Darwinian evolutionary hypothesis; in particular, the multi-stage model of Armitage and Doll (Br. J. Cancer 1954:8;1-12), the two-mutation model of Moolgavkar, Venzon, and Knudson (MVK) (Math. Biosci. 1979:47;55-77), the generalized MVK model of Little (Biometrics 1995:51;1278-1291) and various generalizations of these incorporating effects of GI (Little and Wright Math. Biosci. 2003:183;111-134; Little et al. J. Theoret. Biol. 2008:254;229-238).

    PMID:
    20406436
    [PubMed - indexed for MEDLINE]
    PMCID: PMC2873266
    Free PMC Article

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