J Clin Invest. 1991 May;87(5):1710-5.

Apoptosis as a mechanism of cell death in cultured T lymphoblasts acutely infected with HIV-1.

Terai C, Kornbluth RS, Pauza CD, Richman DD, Carson DA.

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Department of Medicine, University of California at San Diego, La Jolla 92093.

Abstract

The mechanisms by which HIV-1 infection kills T lymphocytes are not clearly established. Apoptosis is an internally programmed cell death pathway that may regulate both T cell development and senescence, and that is characterized by cleavage of DNA at internucleosomal regions. The present experiments show that acute HIV-1 infection of MT2 lymphoblasts and activated normal peripheral blood mononuclear cells induces apoptosis. The addition of anti-gp120 neutralizing antibody, after HIV-1 infection of MT2 cells, permitted sustained high levels of viral replication, but blocked apoptosis and cell death. Apoptosis may account for the direct cytopathologic effects of HIV-1 in T cells.

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