J Immune Based Ther Vaccines. 2010 Feb 4;8:1.

CD40mAb adjuvant induces a rapid antibody response that may be beneficial in post-exposure prophylaxis.

Bhagawati-Prasad VN, De Leenheer E, Keefe NP, Ryan LA, Carlring J, Heath AW.

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Department of Infection and Immunity, University of Sheffield Medical School, Beech Hill Rd, Sheffield S10 2RX, UK. a.w.heath@shef.ac.uk.

Abstract

Active vaccination can be effective as a post-exposure prophylaxis, but the rapidity of the immune response induced, relative to the incubation time of the pathogen, is critical. We show here that CD40mAb conjugated to antigen induces a more rapid specific antibody response than currently used immunological adjuvants, alum and monophosphoryl lipid A.

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PMCID: PMC2824643

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