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    Mol Brain. 2010 Feb 5;3:7.

    Presenilins and the gamma-secretase: still a complex problem.

    Small DH, Klaver DW, Foa L.

    Source

    Menzies Research Institute, University of Tasmania, Hobart, Tasmania 7001, Australia. d.h.small@menzies.utas.edu.au

    Abstract

    The presenilins form part of a complex of membrane proteins that are involved in the proteolytic cleavage of cell-surface molecules. This article reviews the history of the discovery of the presenilins, their role in the pathogenesis of Alzheimer's disease and in the metabolism of the amyloid-beta precursor protein. Unanswered questions about their biochemical mechanism of action and their effects on Ca2+ homeostasis are examined.

    PMID:
    20181106
    [PubMed - indexed for MEDLINE]
    PMCID: PMC2845129
    Free PMC Article

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