Bioinformatics. 2010 Apr 1;26(7):985-6. Epub 2010 Feb 15.

iPHACE: integrative navigation in pharmacological space.

Garcia-Serna R, Ursu O, Oprea TI, Mestres J.

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Chemogenomics Laboratory, Research Unit on Biomedical Informatics (GRIB), Institut Municipal d'Investigació Mèdica and Universitat Pompeu Fabra, Doctor Aiguader 88, 08003 Barcelona, Catalonia, Spain.

Abstract

SUMMARY: The increasing availability of experimentally determined binding affinities for drugs on multiple protein targets requires the design of specific mining and visualization tools that graphically integrate chemical and biological data in an efficient environment. With this aim, we developed iPHACE, an integrative web-based tool to navigate in the pharmacological space defined by small molecule drugs contained in the IUPHAR-DB, with additional interactions present in PDSP. Extending beyond traditional querying and filtering tools, iPHACE offers a means to extract knowledge from the target profile of drugs as well as from the drug profile of protein targets. AVAILABILITY: iPHACE is available at http://cgl.imim.es/iphace/ (EU site) and http://agave.health.unm.edu/iphace/ (US mirror).

PMID:: 20156991; [PubMed - indexed for MEDLINE]
PMCID: PMC2844997

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Publication Types, MeSH Terms, Substances, Grant Support

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Proteins

Grant Support

5U54MH084690-02/MH/NIMH NIH HHS/United States

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