J Hered. 1991 Mar-Apr;82(2):134-9.

The androgen receptor gene is located on a highly conserved region of the X chromosomes of marsupial and monotreme as well as eutherian mammals.

Spencer JA, Watson JM, Lubahn DB, Joseph DR, French FS, Wilson EM, Graves JA.

Source

Department of Genetics and Human Variation, La Trobe University, Bundoora, Victoria, Australia.

Abstract

The androgen receptor gene (AR), which is located on the long arm of the human X chromosome, was mapped by somatic cell analysis and in situ hybridization in marsupial and monotreme species. Both methods demonstrated that it was located on the X chromosome in each marsupial species, and also in the platypus. We conclude that this gene is part of a highly conserved region of the mammalian X, represented by the human Xq, which formed part of the X chromosome in a mammalian ancestor 150 million years ago. Since this gene is located proximally on the long arm of the monotreme X, which is G-band homologous to the Y and apparently exempt from X chromosome inactivation, the conservation of this region has evidently not depended on its isolation by X-Y differentiation or on X inactivation.

PMID:: 2013687; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Supplemental Content

Save items

Related citations in PubMed

The X chromosome of monotremes shares a highly conserved region with the eutherian and marsupial X chromosomes despite the absence of X chromosome inactivation. [Proc Natl Acad Sci U S A. 1990]
The X chromosome of monotremes shares a highly conserved region with the eutherian and marsupial X chromosomes despite the absence of X chromosome inactivation.
Watson JM, Spencer JA, Riggs AD, Graves JA. Proc Natl Acad Sci U S A. 1990 Sep; 87(18):7125-9.
The X chromosome of marsupials shares a highly conserved region with eutherians. [Genomics. 1991]
The X chromosome of marsupials shares a highly conserved region with eutherians.
Spencer JA, Watson JM, Graves JA. Genomics. 1991 Apr; 9(4):598-604.
Gene mapping studies confirm the homology between the platypus X and echidna X1 chromosomes and identify a conserved ancestral monotreme X chromosome. [Chromosoma. 1992]
Gene mapping studies confirm the homology between the platypus X and echidna X1 chromosomes and identify a conserved ancestral monotreme X chromosome.
Watson JM, Riggs A, Graves JA. Chromosoma. 1992 Oct; 101(10):596-601.
Review Mammalian genome evolution: new clues from comparisons of eutherians, marsupials and monotremes. [Comp Biochem Physiol A Comp Ph...]
Review Mammalian genome evolution: new clues from comparisons of eutherians, marsupials and monotremes.
Graves JA. Comp Biochem Physiol A Comp Physiol. 1991; 99(1-2):5-11.
Review The monotreme genome: a patchwork of reptile, mammal and unique features? [Comp Biochem Physiol A Mol Int...]
Review The monotreme genome: a patchwork of reptile, mammal and unique features?
Grützner F, Deakin J, Rens W, El-Mogharbel N, Marshall Graves JA. Comp Biochem Physiol A Mol Integr Physiol. 2003 Dec; 136(4):867-81.

See reviews... See all...

Cited by 3 PubMed Central articles

The multiple sex chromosomes of platypus and echidna are not completely identical and several share homology with the avian Z. [Genome Biol. 2007]
The multiple sex chromosomes of platypus and echidna are not completely identical and several share homology with the avian Z.
Rens W, O'Brien PC, Grützner F, Clarke O, Graphodatskaya D, Tsend-Ayush E, Trifonov VA, Skelton H, Wallis MC, Johnston S, et al. Genome Biol. 2007; 8(11):R243.
Resolution and evolution of the duck-billed platypus karyotype with an X1Y1X2Y2X3Y3X4Y4X5Y5 male sex chromosome constitution. [Proc Natl Acad Sci U S A. 2004]
Resolution and evolution of the duck-billed platypus karyotype with an X1Y1X2Y2X3Y3X4Y4X5Y5 male sex chromosome constitution.
Rens W, Grützner F, O'brien PC, Fairclough H, Graves JA, Ferguson-Smith MA. Proc Natl Acad Sci U S A. 2004 Nov 16; 101(46):16257-61. Epub 2004 Nov 8.
The first comprehensive genetic linkage map of a marsupial: the tammar wallaby (Macropus eugenii). [Genetics. 2002]
The first comprehensive genetic linkage map of a marsupial: the tammar wallaby (Macropus eugenii).
Zenger KR, McKenzie LM, Cooper DW. Genetics. 2002 Sep; 162(1):321-30.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

The androgen receptor gene is located on a highly conserved region of the X chro...
The androgen receptor gene is located on a highly conserved region of the X chromosomes of marsupial and monotreme as well as eutherian mammals.
J Hered. 1991 Mar-Apr ;82(2):134-9.

PubMed
Gene ontology analysis for RNA-seq: accounting for selection bias.
Gene ontology analysis for RNA-seq: accounting for selection bias.
Genome Biol. 2010 ;11(2):R14. Epub 2010 Feb 4 .

PubMed
The roles of residues 5 and 9 of the recognition helix of Lac repressor in lac o...
The roles of residues 5 and 9 of the recognition helix of Lac repressor in lac operator binding.
J Mol Biol. 1991 Mar 20 ;218(2):313-21.

PubMed
Interleukin-8 mediates resistance to antiangiogenic agent sunitinib in renal cel...
Interleukin-8 mediates resistance to antiangiogenic agent sunitinib in renal cell carcinoma.
Cancer Res. 2010 Feb 1 ;70(3):1063-71. Epub 2010 Jan 26 .

PubMed
Analysis of the DNA-binding and activation properties of the human transcription...
Analysis of the DNA-binding and activation properties of the human transcription factor AP-2.
Genes Dev. 1991 Apr ;5(4):670-82.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

The androgen receptor gene is located on a highly conserved region of the X chromosomes of marsupial and monotreme as well as eutherian mammals.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Medical

Libraries

Supplemental Content

Save items

Related citations in PubMed

Cited by 3 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information