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    Genome Biol. 2010;11(2):R13. Epub 2010 Feb 3.

    Inferring the functions of longevity genes with modular subnetwork biomarkers of Caenorhabditis elegans aging.

    Source

    Department of Medical Biophysics, University of Toronto, 610 University Avenue, Toronto, M5G 2M9, Canada.

    Abstract

    A central goal of biogerontology is to identify robust gene-expression biomarkers of aging. Here we develop a method where the biomarkers are networks of genes selected based on age-dependent activity and a graph-theoretic property called modularity. Tested on Caenorhabditis elegans, our algorithm yields better biomarkers than previous methods - they are more conserved across studies and better predictors of age. We apply these modular biomarkers to assign novel aging-related functions to poorly characterized longevity genes.

    PMID:
    20128910
    [PubMed - indexed for MEDLINE]
    PMCID: PMC2872873
    Free PMC Article

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