Molecules. 2010 Jan 21;15(1):460-501.

Total synthesis of annonaceous acetogenins belonging to the non-adjacent bis-THF and non-adjacent THF-THP sub-classes.

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The School of Chemistry, The University of Southampton, Highfield, Southampton SO171BJ, UK.

Abstract

The synthesis of the subgroups of acetogenins containing non-adjacent bis-THF and non-adjacent THF-THP core units is reviewed. Specifically, total syntheses of gigantecin, 4-deoxygigantecin, cis-sylvaticin, squamostatin-C, squamostatin-D, sylvaticin and mucocin are discussed.

PMID:: 20110904; [PubMed - indexed for MEDLINE]

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