A new polyunsaturated brominated fatty acid from a Haliclona sponge

Satoe Aratake; Agus Trianto; Novriyandi Hanif; Nicole J de Voogd; Junichi Tanaka

doi:10.3390/md7040523

A new polyunsaturated brominated fatty acid from a Haliclona sponge

Mar Drugs. 2009 Nov 2;7(4):523-7. doi: 10.3390/md7040523.

Authors

Satoe Aratake¹, Agus Trianto, Novriyandi Hanif, Nicole J de Voogd, Junichi Tanaka

Affiliation

¹ Department of Chemistry, Biology and Marine Science, University of the Ryukyus, Nishihara, Okinawa, Japan. k088302@eve.u-ryukyu.ac.jp

Abstract

A new polyunsaturated brominated fatty acid possessing acetylenic bonds 1 was isolated from the Indonesian sponge Haliclona sp. The structure of compound 1 was elucidated by analyzing its spectral data. It showed moderate cytotoxicity against cultured cells.

Keywords: cytotoxicity; fatty acid; sponge.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkynes / chemistry
Alkynes / isolation & purification*
Alkynes / pharmacology
Animals
Anti-Infective Agents / chemistry
Anti-Infective Agents / isolation & purification*
Anti-Infective Agents / pharmacology
Cell Line
Cytotoxins / chemistry
Cytotoxins / isolation & purification*
Cytotoxins / pharmacology
Fatty Acids, Unsaturated / chemistry
Fatty Acids, Unsaturated / isolation & purification*
Fatty Acids, Unsaturated / pharmacology
Haliclona / chemistry*
Indonesia
Microbial Sensitivity Tests
Rats

Substances

6-bromoicosa-3,5,8,13,15-pentaene-11,19-diynoic acid
Alkynes
Anti-Infective Agents
Cytotoxins
Fatty Acids, Unsaturated