Trends Genet. 1991 Jan;7(1):15-21.

Chemical mutagenesis and fine-structure functional analysis of the mouse genome.

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Biology Division, Oak Ridge National Laboratory, TN 37831-8077.

Abstract

Heritable mutations constitute important raw materials for mammalian developmental genetics and general genome studies. Mutations induced by high-efficiency chemical mutagenesis of germ cells in mice can be used in genetic and molecular studies to complement physical-mapping strategies and to examine the nature and extent of the functional complexities hidden within the mammalian genome.

PMID:: 2003334; [PubMed - indexed for MEDLINE]

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Chemical mutagenesis and fine-structure functional analysis of the mouse genome.

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