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    J Clin Microbiol. 2010 Feb;48(2):606-8. Epub 2009 Dec 23.

    Evaluation of diagnostic tests for Clostridium difficile infection.

    Source

    Department of Microbiology, City Hospital, Dudley Road, Birmingham, United Kingdom.

    Abstract

    We evaluated toxigenic Clostridium difficile detection by a lateral flow assay for antigen and toxin, an enzyme immunoassay, and two commercial PCR methods. Compared to the cell cytotoxicity neutralization assay and toxigenic culture, both toxin detection methods lacked sensitivity. PCR following combined antigen and toxin detection provided the most useful diagnostic information.

    PMID:
    20032256
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC2815642
    Free PMC Article

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