J Biol. 2009;8(11):95. Epub 2009 Dec 14.

Promoter architecture and the evolvability of gene expression.

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Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, 76100, Israel. itay.tirosh@weizmann.ac.il

Abstract

Evolutionary changes in gene expression are a main driver of phenotypic evolution. In yeast, genes that have rapidly diverged in expression are associated with particular promoter features, including the presence of a TATA box, a nucleosome-covered promoter and unstable tracts of tandem repeats. Here, we discuss how these promoter properties may confer an inherent capacity for flexibility of expression.

PMID:: 20017897; [PubMed - indexed for MEDLINE]
PMCID: PMC2804285

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