Crit Care. 2009;13(6):1009. Epub 2009 Dec 7.

Host immune response in sepsis due to ventilator-associated pneumonia: how is it different?

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Division of Infectious Diseases, The Warren Alpert Medical School of Brown University, The Miriam Hospital, Providence, RI 02906, USA. eirini.christaki@gmail.com

Abstract

Current evidence regarding potentially different host response mechanisms in sepsis according to the type of initiating infection is sporadic. It is possible that alterations in cell populations, variations in effector molecules, and the degree of apoptosis differ between sepsis caused by ventilator-associated pneumonia (VAP) and non-VAP sepsis. VAP is one of the most common infections and leading causes of sepsis in the intensive care unit, and mortality remains high. A better understanding of the unique pathophysiologic features of VAP is needed in order to develop interventions that target those specific pathways.

Comment on

Crit Care. 2009;13(6):R172.

PMID:: 20017893; [PubMed - indexed for MEDLINE]
PMCID: PMC2811897

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