J Clin Epidemiol. 1991;44(3):329-34.

Increased incidence of diabetes mellitus in relation to abdominal adiposity in older women.

Kaye SA, Folsom AR, Sprafka JM, Prineas RJ, Wallace RB.

Source

Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis 55455.

Abstract

The relationship between body fat distribution, measured by the ratio of waist-to-hip circumferences (WHR), and the 2 year incidence of diabetes mellitus was examined in a cohort of 41,837 women aged 55-69 years. The 399 women who reported the new onset of diabetes had a significantly greater mean body mass index (kg/m2) and WHR than non-cases. After adjustment for body mass index (BMI), age and education level using multivariate logistic regression, WHR was a significant independent predictor of diabetes in a dose-response fashion. Cases were 4.6 times (95% CI = 3.8, 5.6) more likely than non-cases to be in the upper tertile of WHR and 2.2 times (95% CI = 1.8, 2.7) more likely to be in the middle tertile. Women in the highest tertiles of both WHR and BMI had a 14.4-fold (95% CI = 9.5, 21.9) higher risk of diabetes than women in the lowest tertiles. These results demonstrate that increased abdominal adiposity is a significant independent risk factor for the development of diabetes mellitus in older women.

PMID:: 1999691; [PubMed - indexed for MEDLINE]

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Research Support, U.S. Gov't, P.H.S.

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R01 CA39742/CA/NCI NIH HHS/United States

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