Science. 1991 Feb 15;251(4995):791-4.

Human immunodeficiency virus infection of human-PBL-SCID mice.

Mosier DE, Gulizia RJ, Baird SM, Wilson DB, Spector DH, Spector SA.

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Division of Immunology, Medical Biology Institute, La Jolla, CA 92037.

Abstract

Severe combined immunodeficient (SCID) mice reconstituted with human peripheral blood leukocytes (hu-PBL-SCID mice) have inducible human immune function and may be useful as a small animal model for acquired immunodeficiency syndrome (AIDS) research. Hu-PBL-SCID mice infected with human immunodeficiency virus-1 (HIV-1) contained virus that was recoverable by culture from the peritoneal cavity, spleen, peripheral blood, and lymph nodes for up to 16 weeks after infection; viral sequences were also detected by in situ hybridization and by amplification with the polymerase chain reaction (PCR). Mice could be infected with multiple strains of HIV-1, including LAV-1/Bru, IIIB, MN, SF2, and SF13. HIV-1 infection affected the concentration of human immunoglobulin and the number of CD4+ T cells in the mice. These results support the use of the hu-PBL-SCID mouse for studies of the pathogenesis and treatment of AIDS.

PMID:: 1990441; [PubMed - indexed for MEDLINE]

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