Br J Cancer. 2009 Nov 3;101(9):1497-501. Epub 2009 Sep 29.

Mechanisms of HTLV-1 persistence and transformation.

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National Fund for Scientific Research, Gembloux Agro-Bio Tech, Molecular and Cellular Biology, Gembloux, Belgium.

Abstract

Adult T-cell leukaemia (ATL) is caused by the human T-cell lymphotropic virus type 1 (HTLV-1). HTLV-1 has elaborated strategies to persist and replicate in the presence of a strong immune response. In this review, we summarise these mechanisms and their contribution to T-cell transformation and ATL development.

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