J Rheumatol. 1990 Aug;17(8):994-1002.

Termination of slow acting antirheumatic therapy in rheumatoid arthritis: a 14-year prospective evaluation of 1017 consecutive starts.

Source

Arthritis Center, University of Kansas School of Medicine, Wichita.

Abstract

During a continuous 14-year observation period we prospectively recorded clinical data on all patients with rheumatoid arthritis (RA) attending an outpatient clinic. Six hundred seventy-one patients received 1017 new administrations of slow acting antirheumatic drugs during more than 2000 patient years of observation. The median time to discontinuation for intramuscular gold, auranofin, hydroxychloroquine or penicillamine was 2 years or less, but was 4.25 years for methotrexate (p = 0.008 vs all other drugs combined). Adverse reactions were a more common reason for discontinuation than efficacy, and both were less common in patients taking methotrexate (p less than 0.01). Neither disease duration, disease severity, or demographic factors were useful predictors of discontinuation. Since controlled clinical trials do not provide long-term outcome assessments, measurement of time to termination is a practical tool to estimate drug inefficacy.

PMID:: 1976811; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Medical

Molecular Biology Databases

Libraries

LinkOut Holdings

Supplemental Content

Save items

Related citations in PubMed

A long-term five-year randomized controlled trial of hydroxychloroquine, sodium aurothiomalate, auranofin and penicillamine in the treatment of patients with rheumatoid arthritis. [Br J Rheumatol. 1998]
A long-term five-year randomized controlled trial of hydroxychloroquine, sodium aurothiomalate, auranofin and penicillamine in the treatment of patients with rheumatoid arthritis.
Jessop JD, O'Sullivan MM, Lewis PA, Williams LA, Camilleri JP, Plant MJ, Coles EC. Br J Rheumatol. 1998 Sep; 37(9):992-1002.
Review Rheumatoid arthritis therapy: the slow-acting agents. [Hosp Pract (Off Ed). 1989]
Review Rheumatoid arthritis therapy: the slow-acting agents.
Hardin JG Jr. Hosp Pract (Off Ed). 1989 Jun 15; 24(6):163-8, 170, 173-8.
Review DMARDs in the treatment of rheumatoid arthritis: current agents and future developments. [Int J Clin Pract. 2000]
Review DMARDs in the treatment of rheumatoid arthritis: current agents and future developments.
Simon LS. Int J Clin Pract. 2000 May; 54(4):243-9.
Toxicity of anti-rheumatic drugs in a randomized clinical trial of early rheumatoid arthritis. [Rheumatology (Oxford). 2000]
Toxicity of anti-rheumatic drugs in a randomized clinical trial of early rheumatoid arthritis.
van Jaarsveld CH, Jahangier ZN, Jacobs JW, Blaauw AA, van Albada-Kuipers GA, ter Borg EJ, Brus HL, Schenk Y, van Der Veen MJ, Bijlsma JW. Rheumatology (Oxford). 2000 Dec; 39(12):1374-82.
Aggressive treatment in early rheumatoid arthritis: a randomised controlled trial. On behalf of the Rheumatic Research Foundation Utrecht, The Netherlands. [Ann Rheum Dis. 2000]
Aggressive treatment in early rheumatoid arthritis: a randomised controlled trial. On behalf of the Rheumatic Research Foundation Utrecht, The Netherlands.
van Jaarsveld CH, Jacobs JW, van der Veen MJ, Blaauw AA, Kruize AA, Hofman DM, Brus HL, van Albada-Kuipers GA, Heurkens AH, ter Borg EJ, et al. Ann Rheum Dis. 2000 Jun; 59(6):468-77.

See reviews... See all...

Cited by 26 PubMed Central articles

The Trends of DMARDS prescribed in Rheumatoid Arthritis Patients in Malaysia. [Oman Med J. 2009]
The Trends of DMARDS prescribed in Rheumatoid Arthritis Patients in Malaysia.
Sulaiman W, Toib A, Chandrashekhar G, Arshad A. Oman Med J. 2009 Oct; 24(4):260-06.
Periodontal status of rheumatoid arthritis patients in khartoum state. [BMC Res Notes. 2011]
Periodontal status of rheumatoid arthritis patients in khartoum state.
Abdelsalam SK, Hashim NT, Elsalamabi EM, Gismalla BG. BMC Res Notes. 2011 Oct 28; 4(1):460. Epub 2011 Oct 28.
Minocycline and doxycycline therapy in community patients with rheumatoid arthritis: prescribing patterns, patient-level determinants of use, and patient-reported side effects. [Arthritis Res Ther. 2011]
Minocycline and doxycycline therapy in community patients with rheumatoid arthritis: prescribing patterns, patient-level determinants of use, and patient-reported side effects.
Smith CJ, Sayles H, Mikuls TR, Michaud K. Arthritis Res Ther. 2011; 13(5):R168. Epub 2011 Oct 18.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Termination of slow acting antirheumatic therapy in rheumatoid arthritis: a 14-y...
Termination of slow acting antirheumatic therapy in rheumatoid arthritis: a 14-year prospective evaluation of 1017 consecutive starts.
J Rheumatol. 1990 Aug ;17(8):994-1002.

PubMed
Suppressive effect of secretory phospholipase A2 inhibitory peptide on interleuk...
Suppressive effect of secretory phospholipase A2 inhibitory peptide on interleukin-1beta-induced matrix metalloproteinase production in rheumatoid synovial fibroblasts, and its antiarthritic activity in hTNFtg mice.
Arthritis Res Ther. 2009 ;11(5):R138. Epub 2009 Sep 18 .

PubMed
Single base mutation in the type II procollagen gene (COL2A1) as a cause of prim...
Single base mutation in the type II procollagen gene (COL2A1) as a cause of primary osteoarthritis associated with a mild chondrodysplasia.
Proc Natl Acad Sci U S A. 1990 Sep ;87(17):6565-8.

PubMed
Risk factors for onset of osteoarthritis of the knee in older adults: a systemat...
Risk factors for onset of osteoarthritis of the knee in older adults: a systematic review and meta-analysis.
Osteoarthritis Cartilage. 2010 Jan ;18(1):24-33. Epub 2009 Sep 2 .

PubMed
A prospective nationwide cross-sectional study of NSAID usage in 1331 patients w...
A prospective nationwide cross-sectional study of NSAID usage in 1331 patients with ankylosing spondylitis.
J Rheumatol. 1990 Jun ;17(6):801-3.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Termination of slow acting antirheumatic therapy in rheumatoid arthritis: a 14-year prospective evaluation of 1017 consecutive starts.

Source

Abstract

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Other Literature Sources

Medical

Molecular Biology Databases

Libraries

Supplemental Content

Save items

Related citations in PubMed

Cited by 26 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information