FEBS Lett. 2009 Oct 6;583(19):3241-6. Epub 2009 Sep 12.

Human cytosolic tRNase ZL can downregulate gene expression through miRNA.

Elbarbary RA, Takaku H, Uchiumi N, Tamiya H, Abe M, Nishida H, Nashimoto M.

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Department of Applied Life Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Niigata 956-8603, Japan.

Abstract

A long form of tRNase Z (tRNase ZL) can cleave any target RNA at any desired site under the direction of artificial small guide RNA including approximately 25-nucleotide hook-shaped RNA. Here we show that human miR-103 can form a hook structure to guide target RNA cleavage by human cytosolic tRNase ZL in vitro. In vivo analyses using luciferase mRNAs modified to contain miR-103 target sequences in their 3' untranslated regions indicated that miR-103 downregulates gene expression through directing mRNA cleavage by tRNase ZL. The present data suggest the possibility that human cytosolic tRNase ZL modulates gene expression through a subset of microRNAs in the cells.

PMID:: 19751732; [PubMed - indexed for MEDLINE]

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