Biochim Biophys Acta. 2010 Jan-Feb;1799(1-2):3-14. Epub 2009 Sep 11.

Nuclear functions of the HMG proteins.

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School of Molecular Biosciences, Washington State University, Biotechnology/Life Sciences Bldg., Rm. 143, Pullman, WA 99164-7520, USA. reevesr@wsu.edu

Abstract

Although the three families of mammalian HMG proteins (HMGA, HMGB and HMGN) participate in many of the same nuclear processes, each family plays its own unique role in modulating chromatin structure and regulating genomic function. This review focuses on the similarities and differences in the mechanisms by which the different HMG families impact chromatin structure and influence cellular phenotype. The biological implications of having three architectural transcription factor families with complementary, but partially overlapping, nuclear functions are discussed.

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PMCID:: PMC2818135

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