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    Nature. 1990 Jun 21;345(6277):686-92.

    A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo.

    Rosner MH, Vigano MA, Ozato K, Timmons PM, Poirier F, Rigby PW, Staudt LM.

    Source

    Metabolism Branch, National Cancer Institute, Bethesda, Maryland 20892.

    Abstract

    The murine oct-3 gene encodes a transcription factor containing a POU-specific domain and a homeodomain. In marked contrast to other homeodomain-encoding genes, oct-3 is expressed in the totipotent and pluripotent stem cells of the pregastrulation embryo and is down-regulated during differentiation to endoderm and mesoderm, suggesting that it has a role in early development. The oct-3 gene is also expressed in primordial germ cells and in the female germ line.

    PMID:
    1972777
    [PubMed - indexed for MEDLINE]

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