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    Mol Cell Biol. 1990 Jul;10(7):3578-83.

    Developmentally regulated protein-tyrosine kinase genes in Dictyostelium discoideum.

    Tan JL, Spudich JA.

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    Department of Cell Biology, Stanford University School of Medicine, California 94305.

    Abstract

    Dictyostelium discoideum, an organism that undergoes development and that is amenable to biochemical and molecular genetic approaches, is an attractive model organism with which to study the role of tyrosine phosphorylation in cell-cell communication. We report the presence of protein-tyrosine kinase genes in D. discoideum. Screening of a Dictyostelium cDNA expression library with an anti-phosphotyrosine antibody identifies fusion proteins that exhibit protein-tyrosine kinase activity. Two distinct cDNAs were identified and isolated. Though highly homologous to protein kinases in general, these kinases do not exhibit many of the hallmarks of protein-tyrosine kinases of higher eucaryotes. In addition, these genes are developmentally regulated, which suggests a role for tyrosine phosphorylation in controlling Dictyostelium development.

    PMID:
    1972546
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC360793
    Free PMC Article

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