Lancet. 1990 Jun 30;335(8705):1565-8.

Prognostic importance of occult axillary lymph node micrometastases from breast cancers. International (Ludwig) Breast Cancer Study Group.

[No authors listed]

Abstract

Serial sectioning of ipsilateral axillary lymph nodes judged to be disease-free after routine histological examination revealed micrometastases in 83 (9%) of 921 breast cancer subjects. These patients had a poorer disease-free (p = 0.003) and overall (p = 0.002) survival after 5 years' median follow-up than did patients whose nodes remained negative on serial sectioning. The presence of axillary lymph node micrometastases correlated with the presence of vascular invasion and tumour size (p less than 0.0001 and p = 0.02, respectively). The presence of occult micrometastases remained statistically significant after adjusting for other prognostic factors. The detection of these micrometastases in lymph nodes may identify a high risk "node-negative" population and should be considered as part of the routine pathology examination.

Comment in

PMID:: 1972494; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Supplemental Content

Save items

Related citations in PubMed

Role of immunohistochemical detection of lymph-node metastases in management of breast cancer. International Breast Cancer Study Group. [Lancet. 1999]
Role of immunohistochemical detection of lymph-node metastases in management of breast cancer. International Breast Cancer Study Group.
Cote RJ, Peterson HF, Chaiwun B, Gelber RD, Goldhirsch A, Castiglione-Gertsch M, Gusterson B, Neville AM. Lancet. 1999 Sep 11; 354(9182):896-900.
Biological significance of occult micrometastases in histologically negative axillary lymph nodes in breast cancer patients using the recent American Joint Committee on Cancer breast cancer staging system. [Breast J. 2006]
Biological significance of occult micrometastases in histologically negative axillary lymph nodes in breast cancer patients using the recent American Joint Committee on Cancer breast cancer staging system.
Kahn HJ, Hanna WM, Chapman JA, Trudeau ME, Lickley HL, Mobbs BG, Murray D, Pritchard KI, Sawka CA, McCready DR, et al. Breast J. 2006 Jul-Aug; 12(4):294-301.
Prognostic significance of occult axillary lymph node metastases after chemotherapy-induced pathologic complete response of cytologically proven axillary lymph node metastases from breast cancer. [Cancer. 2009]
Prognostic significance of occult axillary lymph node metastases after chemotherapy-induced pathologic complete response of cytologically proven axillary lymph node metastases from breast cancer.
Loya A, Guray M, Hennessy BT, Middleton LP, Buchholz TA, Valero V, Sahin AA. Cancer. 2009 Apr 15; 115(8):1605-12.
Review Sentinel lymph node as a new marker for therapeutic planning in breast cancer patients. [J Surg Oncol. 2004]
Review Sentinel lymph node as a new marker for therapeutic planning in breast cancer patients.
Gipponi M, Bassetti C, Canavese G, Catturich A, Di Somma C, Vecchio C, Nicolò G, Schenone F, Tomei D, Cafiero F. J Surg Oncol. 2004 Mar; 85(3):102-11.
Review Improved axillary staging of breast cancer with sentinel lymphadenectomy. [Ann Surg. 1995]
Review Improved axillary staging of breast cancer with sentinel lymphadenectomy.
Giuliano AE, Dale PS, Turner RR, Morton DL, Evans SW, Krasne DL. Ann Surg. 1995 Sep; 222(3):394-9; discussion 399-401.

See reviews... See all...

Cited by 23 PubMed Central articles

Imprint cytology predicts axillary node status in sentinel lymph node biopsy. [Ulster Med J. 2010]
Imprint cytology predicts axillary node status in sentinel lymph node biopsy.
Bell Z, Cameron I, Dace JS. Ulster Med J. 2010 Sep; 79(3):119-22.
Review Ultrastaging of lymph node in uterine cancers. [J Exp Clin Cancer Res. 2010]
Review Ultrastaging of lymph node in uterine cancers.
Bézu C, Coutant C, Ballester M, Feron JG, Rouzier R, Uzan S, Daraï E. J Exp Clin Cancer Res. 2010 Jan 21; 29:5. Epub 2010 Jan 21.
Review Recent advances in the surgical care of breast cancer patients. [World J Surg Oncol. 2010]
Review Recent advances in the surgical care of breast cancer patients.
Mascaro A, Farina M, Gigli R, Vitelli CE, Fortunato L. World J Surg Oncol. 2010 Jan 20; 8:5. Epub 2010 Jan 20.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

Prognostic importance of occult axillary lymph node micrometastases from breast ...
Prognostic importance of occult axillary lymph node micrometastases from breast cancers. International (Ludwig) Breast Cancer Study Group.
Lancet. 1990 Jun 30 ;335(8705):1565-8.

PubMed
Growth factor receptor-bound protein-7 (Grb7) as a prognostic marker and therape...
Growth factor receptor-bound protein-7 (Grb7) as a prognostic marker and therapeutic target in breast cancer.
Ann Oncol. 2010 Mar ;21(3):466-73. Epub 2009 Aug 28 .

PubMed
Experimental biology of cerebral hypoxia-ischemia: relation to perinatal brain d...
Experimental biology of cerebral hypoxia-ischemia: relation to perinatal brain damage.
Pediatr Res. 1990 Apr ;27(4 Pt 1):317-26.

PubMed
The metastasis efficiency modifier ribosomal RNA processing 1 homolog B (RRP1B) ...
The metastasis efficiency modifier ribosomal RNA processing 1 homolog B (RRP1B) is a chromatin-associated factor.
J Biol Chem. 2009 Oct 16 ;284(42):28660-73. Epub 2009 Aug 26 .

PubMed
Hypothesis: does breast cancer originate in utero?
Hypothesis: does breast cancer originate in utero?
Lancet. 1990 Apr 21 ;335(8695):939-40.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Prognostic importance of occult axillary lymph node micrometastases from breast cancers. International (Ludwig) Breast Cancer Study Group.

Abstract

Comment in

Publication Types, MeSH Terms

Publication Types

MeSH Terms

LinkOut - more resources

Other Literature Sources

Medical

Libraries

Supplemental Content

Save items

Related citations in PubMed

Cited by 23 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information