Crit Care. 2009;13(4):178. Epub 2009 Aug 14.

Arginine vasopressin in septic shock: supplement or substitute for norepinephrine?

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Investigational Intensive Care Unit, Department of Anesthesiology, The University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, USA. serehber@utmb.edu

Abstract

In the current issue of Critical Care, Simon and coworkers investigated the effects of first-line arginine vasopressin (AVP) on organ function and systemic metabolism compared with norepinephrine in a pig model of fecal peritonitis. AVP was titrated according to the mean arterial pressure suggesting a vasopressor rather than a hormone replacement therapy. The study provides some evidence for the safety of this therapeutic approach. It needs to be determined whether AVP is most beneficial as a constant low-dose infusion to supplement norepinephrine or in higher doses than currently recommended to substitute norepinephrine. In addition, future studies are warranted to evaluate whether a first-line therapy of AVP is superior to a last-resort administration.

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Crit Care. 2009;13(4):R113.

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PMCID: PMC2750182

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Chemical compound information

Norepinephrine

MW: 169.17 g/mol

MF: C₈H₁₁NO₃

See 21 citations for this compound....

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Arginine vasopressin in septic shock: supplement or substitute for norepinephrine?

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