Crit Care. 2009;13(4):311. Epub 2009 Aug 14.

Targeting the ubiquitin proteasome pathway for the treatment of septic shock in patients.

Source

Ottawa Health Research Institute, Ottawa, ON, Canada K1Y 4E9. jzbrun@yahoo.com

Abstract

Endotoxic shock is a serious systemic inflammatory response to an external biological stressor. The responsiveness of NF-kappaB is built upon rapid protein modification and degradation involving the ubiquitin proteasome pathway. Using transgenic mice, we have obtained in vivo evidence that interference with this pathway can alleviate the symptoms of toxic shock. We posit that administration of proteasome inhibitors may enhance the survival of patients with septic shock.

PMID:: 19691815; [PubMed - indexed for MEDLINE]
PMCID: PMC2750148

Free PMC Article

Images from this publication.See all images (3) Free text

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Shock - MedlinePlus Health Information

Libraries

LinkOut Holdings

Supplemental Content

Related citations

Review Targeting the ubiquitin-proteasome pathway in breast cancer therapy. [Future Oncol. 2006]
Review Targeting the ubiquitin-proteasome pathway in breast cancer therapy.
Dees EC, Orlowski RZ. Future Oncol. 2006 Feb; 2(1):121-35.
Review The proteasome: a novel target for anticancer therapy. [Clin Transl Oncol. 2006]
Review The proteasome: a novel target for anticancer therapy.
Montagut C, Rovira A, Albanell J. Clin Transl Oncol. 2006 May; 8(5):313-7.
Enhancement of radiosensitivity by proteasome inhibition: implications for a role of NF-kappaB. [Int J Radiat Oncol Biol Phys. 2001]
Enhancement of radiosensitivity by proteasome inhibition: implications for a role of NF-kappaB.
Russo SM, Tepper JE, Baldwin AS Jr, Liu R, Adams J, Elliott P, Cusack JC Jr. Int J Radiat Oncol Biol Phys. 2001 May 1; 50(1):183-93.
The human immunodeficiency virus (HIV)-1 protease inhibitor saquinavir inhibits proteasome function and causes apoptosis and radiosensitization in non-HIV-associated human cancer cells. [Cancer Res. 2002]
The human immunodeficiency virus (HIV)-1 protease inhibitor saquinavir inhibits proteasome function and causes apoptosis and radiosensitization in non-HIV-associated human cancer cells.
Pajonk F, Himmelsbach J, Riess K, Sommer A, McBride WH. Cancer Res. 2002 Sep 15; 62(18):5230-5.
Review The role of nuclear factor-kappaB in the biology and treatment of multiple myeloma. [Semin Oncol. 2001]
Review The role of nuclear factor-kappaB in the biology and treatment of multiple myeloma.
Berenson JR, Ma HM, Vescio R. Semin Oncol. 2001 Dec; 28(6):626-33.

See reviews... See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Free in PMC
Free full text articles in PMC

Recent activity

Clear Turn Off Turn On

Targeting the ubiquitin proteasome pathway for the treatment of septic shock in ...
Targeting the ubiquitin proteasome pathway for the treatment of septic shock in patients.
Crit Care. 2009 ;13(4):311. Epub 2009 Aug 14 .

PubMed
Efficacy and safety of tifacogin (recombinant tissue factor pathway inhibitor) i...
Efficacy and safety of tifacogin (recombinant tissue factor pathway inhibitor) in severe sepsis: a randomized controlled trial.
JAMA. 2003 Jul 9 ;290(2):238-47.

PubMed
Mechanisms of sepsis-induced organ dysfunction.
Mechanisms of sepsis-induced organ dysfunction.
Crit Care Med. 2007 Oct ;35(10):2408-16.

PubMed
Discrepancies between brain CT imaging and severely raised intracranial pressure...
Discrepancies between brain CT imaging and severely raised intracranial pressure proven by ventriculostomy in adults with pneumococcal meningitis.
J Neurol. 2002 Sep ;249(9):1292-7.

PubMed
Science review: quantitative acid-base physiology using the Stewart model.
Science review: quantitative acid-base physiology using the Stewart model.
Crit Care. 2004 Dec ;8(6):448-52. Epub 2004 Jul 2 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to: