Genetics. 1990 Jan;124(1):157-63.

Length heteroplasmy of sturgeon mitochondrial DNA: an illegitimate elongation model.

Buroker NE, Brown JR, Gilbert TA, O'Hara PJ, Beckenbach AT, Thomas WK, Smith MJ.

Source

School of Medicine, Department of Pediatrics, University of Washington, Seattle 98195.

Abstract

Extensive length polymorphism and heteroplasmy (multiple forms within an individual) of the D-loop region are observed in mitochondrial DNA of the white sturgeon (Acipenser transmontanus). The nucleotide sequence of this region, for both a short and a long form, shows that the differences are due to variable numbers of a perfect 82-bp direct repeat. We propose a model for the replicative origin of length differences, involving a competitive equilibrium between the heavy strand and the D-loop strand. This model suggests that frequent misalignment in the repeat region prior to elongation, facilitated by a stable secondary structure in the displaced strand, can explain both the polymorphism and heteroplasmy in this species.

PMID:: 1968410; [PubMed - indexed for MEDLINE]
PMCID:: PMC1203902

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Publication Types, MeSH Terms, Substances, Secondary Source ID

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Research Support, Non-U.S. Gov't

MeSH Terms

Substances

DNA, Mitochondrial

Secondary Source ID

GENBANK/X54348

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