Department of Structural Genomics, Neocodex SL, Avda, Charles Darwin 6, Acceso A, Isla de la Cartuja, 41092, Sevilla, Spain.
Abstract
ABSTRACT : The age at natural menopause shows great variability. It has been proposed that early age at menopause is a risk factor for osteoporosis and cardiovascular disease, whereas later age at menopause is a risk factor for breast cancer. In addition, it is thought that the genetic factors accounting for the genetic variability in age at menopause could also play a role in those diseases, as well as infertility in women. In this minireview we comment on the latest genetics and genomics insights into age at natural menopause.