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    J Biol. 2009;8(7):64. Epub 2009 Jul 27.

    From bending DNA to diabetes: the curious case of HMGA1.

    Semple RK.

    Source

    Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0QR, UK. rks16@cam.ac.uk

    Abstract

    Although mice lacking the architectural DNA binding factor HMGA1 are diabetic and express very low levels of the insulin receptor, they have increased insulin sensitivity. A study in BMC Biology now suggests that changes in circulating retinol binding protein partly account for this paradox.

    PMID:
    19664187
    [PubMed - indexed for MEDLINE]
    PMCID: PMC2736670
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