Science. 1991 Nov 22;254(5035):1178-81.

Optical coherence tomography.

Huang D, Swanson EA, Lin CP, Schuman JS, Stinson WG, Chang W, Hee MR, Flotte T, Gregory K, Puliafito CA, et al.

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Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge 02139.

Abstract

A technique called optical coherence tomography (OCT) has been developed for noninvasive cross-sectional imaging in biological systems. OCT uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way that is analogous to ultrasonic pulse-echo imaging. OCT has longitudinal and lateral spatial resolutions of a few micrometers and can detect reflected signals as small as approximately 10(-10) of the incident optical power. Tomographic imaging is demonstrated in vitro in the peripapillary area of the retina and in the coronary artery, two clinically relevant examples that are representative of transparent and turbid media, respectively.

PMID:: 1957169; [PubMed - indexed for MEDLINE]

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1-R01-GM35459-06/GM/NIGMS NIH HHS/United States

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