J Steroid Biochem Mol Biol. 1991 Nov;39(5B):819-28.

Androgen metabolism in the brain.

Source

Istituto di Endocrinologia, Università degli Studi di Milano, Italy.

Abstract

The paper summarizes the most recent views on androgen metabolism in the brain. In particular it will be shown that: (1) the enzyme 5 alpha-reductase is particularly concentrated in the white matter; (2) 5 alpha-reductase is also present in the myelin; 5 alpha-reductase is present in higher concentrations in neurons (isolated or cultured) that in glial cells (astrocytes and oligodendrocytes); (4) only neurons possess the capability of aromatizing androgens to estrogens; and (5) a possible role of steroid metabolism in the control of the process of myelinogenesis is suggested.

PMID:: 1954172; [PubMed - indexed for MEDLINE]

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