Arthritis Rheum. 1991 Nov;34(11):1444-51.

Cathepsin B in synovial cells at the site of joint destruction in rheumatoid arthritis.

Trabandt A, Gay RE, Fassbender HG, Gay S.

Source

Department of Medicine, University of Alabama, Birmingham 35294.

Abstract

Based on the concept that proteolytic enzymes, like cathepsins, are associated with tissue destruction, we investigated the expression of the matrix-degrading cysteine proteinase cathepsin B in synovial tissues from the joints of patients with rheumatoid arthritis. The data indicate an enhanced transcription of cathepsin B in synovial cells when compared with normal fibroblasts, cathepsin B-producing epithelial tumor cells (SW1116), or fibroblasts derived from inflamed tonsils. Immunolocalization of cathepsin B appeared to be restricted mainly to the synovial cells attached to cartilage and bone at sites of rheumatoid joint erosion.

PMID:: 1953821; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

1-P01-DE-08228/DE/NIDCR NIH HHS/United States

LinkOut - more resources

Medical

Libraries

LinkOut Holdings

Supplemental Content

Save items

Related citations in PubMed

Cysteine proteinase cathepsin K mRNA is expressed in synovium of patients with rheumatoid arthritis and is detected at sites of synovial bone destruction. [J Rheumatol. 1998]
Cysteine proteinase cathepsin K mRNA is expressed in synovium of patients with rheumatoid arthritis and is detected at sites of synovial bone destruction.
Hummel KM, Petrow PK, Franz JK, Müller-Ladner U, Aicher WK, Gay RE, Brömme D, Gay S. J Rheumatol. 1998 Oct; 25(10):1887-94.
Expression of the collagenolytic and Ras-induced cysteine proteinase cathepsin L and proliferation-associated oncogenes in synovial cells of MRL/I mice and patients with rheumatoid arthritis. [Matrix. 1990]
Expression of the collagenolytic and Ras-induced cysteine proteinase cathepsin L and proliferation-associated oncogenes in synovial cells of MRL/I mice and patients with rheumatoid arthritis.
Trabandt A, Aicher WK, Gay RE, Sukhatme VP, Nilson-Hamilton M, Hamilton RT, McGhee JR, Fassbender HG, Gay S. Matrix. 1990 Dec; 10(6):349-61.
Collagenase, cathepsin B and cathepsin L gene expression in the synovial membrane of patients with early inflammatory arthritis. [Rheumatology (Oxford). 1999]
Collagenase, cathepsin B and cathepsin L gene expression in the synovial membrane of patients with early inflammatory arthritis.
Cunnane G, FitzGerald O, Hummel KM, Gay RE, Gay S, Bresnihan B. Rheumatology (Oxford). 1999 Jan; 38(1):34-42.
Review Rheumatoid arthritis: targeting the proliferative fibroblasts. [Prog Cell Cycle Res. 2003]
Review Rheumatoid arthritis: targeting the proliferative fibroblasts.
Kramer I, Wibulswas A, Croft D, Genot E. Prog Cell Cycle Res. 2003; 5:59-70.
Review Role of cathepsin K in normal joints and in the development of arthritis. [Curr Drug Targets. 2007]
Review Role of cathepsin K in normal joints and in the development of arthritis.
Salminen-Mankonen HJ, Morko J, Vuorio E. Curr Drug Targets. 2007 Feb; 8(2):315-23.

See reviews... See all...

Cited by 18 PubMed Central articles

The role of osteoprotegerin (OPG) and estrogen receptor (ER-α) gene polymorphisms in rheumatoid arthritis. [Clin Cases Miner Bone Metab. 2...]
The role of osteoprotegerin (OPG) and estrogen receptor (ER-α) gene polymorphisms in rheumatoid arthritis.
Masi L, Maddali Bongi S, Angotti C, Del Monte F, Carbonell Sala S, Basetti M, Amedei A, Falchetti A, Brandi ML. Clin Cases Miner Bone Metab. 2007 May; 4(2):156-60.
Cystatin C influences the autoimmune but not inflammatory response to cartilage type II collagen leading to chronic arthritis development. [Arthritis Res Ther. 2011]
Cystatin C influences the autoimmune but not inflammatory response to cartilage type II collagen leading to chronic arthritis development.
Bäcklund A, Holmdahl M, Mattsson R, Håkansson K, Lindström V, Nandakumar KS, Grubb A, Holmdahl R. Arthritis Res Ther. 2011 Mar 28; 13(2):R54. Epub 2011 Mar 28.
Review Protective mechanisms by cystatin C in neurodegenerative diseases. [Front Biosci (Schol Ed). 2011]
Review Protective mechanisms by cystatin C in neurodegenerative diseases.
Gauthier S, Kaur G, Mi W, Tizon B, Levy E. Front Biosci (Schol Ed). 2011 Jan 1; 3:541-54. Epub 2011 Jan 1.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Cathepsin B in synovial cells at the site of joint destruction in rheumatoid art...
Cathepsin B in synovial cells at the site of joint destruction in rheumatoid arthritis.
Arthritis Rheum. 1991 Nov ;34(11):1444-51.

PubMed
The treatment and prevention of knee osteoarthritis: a tool for clinical decisio...
The treatment and prevention of knee osteoarthritis: a tool for clinical decision-making.
Expert Opin Pharmacother. 2009 Aug ;10(11):1793-804.

PubMed
Intrinsic innervation of the rat knee joint articular capsule and ligaments.
Intrinsic innervation of the rat knee joint articular capsule and ligaments.
Acta Anat (Basel). 1991 ;141(1):8-14.

PubMed
Serious infections in British patients with systemic lupus erythematosus: hospit...
Serious infections in British patients with systemic lupus erythematosus: hospitalisations and mortality.
Lupus. 2009 Jul ;18(8):682-9.

PubMed
Matrix metabolism and healing in the flexor tendon. Experimental studies on rabb...
Matrix metabolism and healing in the flexor tendon. Experimental studies on rabbit tendon.
Scand J Plast Reconstr Surg Hand Surg Suppl. 1991 ;23:1-51.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: