Ann Emerg Med. 1991 Nov;20(11):1243-5.

Intravenous magnesium sulfate in acute, life-threatening asthma.

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Intensive Care Unit, Middlemore Hospital, Auckland, New Zealand.

Erratum in

Ann Emerg Med 1992 Oct;21(10):1272.

Abstract

Magnesium, a physiologic calcium antagonist, is known to have a direct effect on calcium uptake in smooth muscle, resulting in smooth muscle relaxation. Studies of magnesium sulfate infusions in patients with mild or moderate-to-severe acute asthma have shown that it may have a significant bronchodilatory effect, similar to that of salbutamol (albuterol). We present the case of a patient with acute severe life-threatening asthma (initially in cardiorespiratory arrest) who responded to an IV infusion of magnesium sulfate after aggressive pharmacologic management failed to result in clinical improvement.

PMID:: 1952314; [PubMed - indexed for MEDLINE]

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Magnesium Sulfate

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High-dose intravenous magnesium sulfate in the management of life-threatening status asthmaticus. [Intensive Care Med. 1993]
High-dose intravenous magnesium sulfate in the management of life-threatening status asthmaticus.
Sydow M, Crozier TA, Zielmann S, Radke J, Burchardi H. Intensive Care Med. 1993; 19(8):467-71.
Bronchodilating effect of intravenous magnesium sulfate in acute severe bronchial asthma. [Chest. 1990]
Bronchodilating effect of intravenous magnesium sulfate in acute severe bronchial asthma.
Noppen M, Vanmaele L, Impens N, Schandevyl W. Chest. 1990 Feb; 97(2):373-6.
Treatment of status asthmaticus with intravenous magnesium sulfate. [J Asthma. 1991]
Treatment of status asthmaticus with intravenous magnesium sulfate.
Okayama H, Okayama M, Aikawa T, Sasaki M, Takishima T. J Asthma. 1991; 28(1):11-7.
Review Rapid infusion of magnesium sulfate obviates need for intubation in status asthmaticus. [Am J Emerg Med. 1994]
Review Rapid infusion of magnesium sulfate obviates need for intubation in status asthmaticus.
Schiermeyer RP, Finkelstein JA. Am J Emerg Med. 1994 Mar; 12(2):164-6.
Review [Cardiorespiratory and electrolytic changes in status asthmaticus after intravenous administration of magnesium sulfate]. [Orv Hetil. 1993]
Review [Cardiorespiratory and electrolytic changes in status asthmaticus after intravenous administration of magnesium sulfate].
Barzó P, Bíró B, Lipták E, Gyurcsik A, Barzó P Jr, Szabó T. Orv Hetil. 1993 Jul 18; 134(29):1577-80.

See reviews... See all...

Cited by 2 PubMed Central articles

Short and long term treatment of asthma with intravenous nutrients. [Nutr J. 2004]
Short and long term treatment of asthma with intravenous nutrients.
Shrader WA Jr. Nutr J. 2004 May 14; 3:6. Epub 2004 May 14.
Dose-response relationship and time-course of the effect of inhaled magnesium sulphate on airflow in normal and asthmatic subjects. [Br J Clin Pharmacol. 1995]
Dose-response relationship and time-course of the effect of inhaled magnesium sulphate on airflow in normal and asthmatic subjects.
Hill J, Britton J. Br J Clin Pharmacol. 1995 Dec; 40(6):539-44.

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