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    Breast Cancer Res. 2009;11(3):303. Epub 2009 May 18.

    Anti-VEGF therapy as adjuvant therapy: clouds on the horizon?

    Schneider BP, Sledge GW Jr.

    Source

    Indiana University Simon Cancer Center, Indianapolis, IN 46220, USA. bpschnei@iupui.edu

    Abstract

    Anti-angiogenic therapies have demonstrated their value in the setting of advanced cancer, and are being explored for use in micrometastatic disease. Recent preclinical studies suggest that adjuvant anti-vascular endothelial growth factor (VEGF) therapies may increase the risk of metastasis. How concerning are these preclinical studies, and should they affect our willingness to explore anti-VEGF therapy in the adjuvant setting?

    PMID:
    19519950
    [PubMed - indexed for MEDLINE]
    PMCID: PMC2716490
    Free PMC Article

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