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    Science. 1991 Oct 25;254(5031):578-9.

    Cloning and expression of a cocaine-sensitive rat dopamine transporter.

    Kilty JE, Lorang D, Amara SG.

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    Yale University, New Haven, CT 06510.

    Abstract

    The action of dopamine and other monoamine neurotransmitters at synapses is terminated predominantly by high-affinity reuptake into presynaptic terminals by specific sodium-dependent neurotransmitter transport proteins. A complementary DNA encoding a rat dopamine transporter has been isolated that exhibits high sequence similarity with the previously cloned norepinephrine and gamma-aminobutyric acid transporters. Transient expression of the complementary DNA in HeLa cells confirms the cocaine sensitivity of this transporter.

    PMID:
    1948035
    [PubMed - indexed for MEDLINE]

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