Traffic. 2009 Sep;10(9):1209-20. Epub 2009 May 12.

Nuclear trafficking and functions of endocytic proteins implicated in oncogenesis.

Source

Uro-Oncology Research Group, CRUK Cambridge Research Institute, Cambridge CB20RE, UK. joana.borlido@cancer.org.uk

Abstract

A subset of proteins predominantly associated with early endosomes or implicated in clathrin-mediated endocytosis can shuttle between the cytoplasm and the nucleus. Although the endocytic functions of these proteins have been extensively studied, much less effort has been expended in exploring their nuclear roles. Membrane trafficking proteins can affect signalling and proliferation and this can be achieved either at a nuclear or endocytic level. Furthermore, some proteins, such as Huntingtin interacting protein 1, are known as cancer biomarkers. This review will highlight the limits of our understanding of their nuclear functions and the relevance of this to signalling and oncogenesis.

PMID:: 19453971; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Adaptor Proteins, Vesicular Transport

Grant Support

Cancer Research UK/United Kingdom

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Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Medical

Cancer - MedlinePlus Health Information

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