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    Neurosci Lett. 1991 Jul 22;128(2):243-4.

    Additional genes which result in an elevation of acetylcholine levels by mutations in Caenorhabditis elegans.

    Source

    Department of Biochemistry, School of Medicine, Kanazawa University, Japan.

    Abstract

    Four mutant genes (unc-17, unc-18, unc-41 and unc-13) have been identified that result in abnormal accumulation of acetylcholine (ACh). We have now identified 3 more such genes (unc-63, unc-11 and unc-64). In addition to the abnormal accumulation of ACh, mutants in these 7 genes possess common phenotypes in locomotion, resistance to inhibitors of acetylcholinesterase (AChE) and in post-embryonic development. These results suggest that the 7 genes are involved in some related functions.

    PMID:
    1945043
    [PubMed - indexed for MEDLINE]

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