Crit Care. 2009;13(2):135. Epub 2009 Apr 22.

Sepsis-associated delirium: the pro and con of C5a blockade.

Source

General Intensive Care Unit, Raymond Poincaré Hospital (AP-HP), University of Versailles SQY (UniverSud Paris), 104 boulevard Raymond Poincaré, 92380 Garches, France. djillali.annane@rpc.aphp.fr

Abstract

The intimate mechanisms of sepsis-induced delirium are unknown. Among the potential contributing factors, the breakdown of the blood-brain barrier is considered a key determinant of brain dysfunction. The complement activation is paramount to an appropriate activation of the central nervous system during stress. C3a and C5a have been extensively studied and may be involved in sepsis-induced delirium. Here we discuss the pro and con for inhibiting C5a to attenuate brain damage during sepsis. In particular, we discuss the hypothesis that C5a increased blood-brain barrier permeability amy ease the brain to mount an appropriate response to sepsis. Thus, blockade of C5a may be detrimental, resulting in an attenuated response of the stress system.

Comment on

Crit Care. 2009;13(1):R12.

PMID:: 19439043; [PubMed - indexed for MEDLINE]
PMCID: PMC2689478

Free PMC Article

Publication Types, MeSH Terms, Substances

Publication Types

Comment

MeSH Terms

Substances

Complement C5a

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Medical

Libraries

LinkOut Holdings

Supplemental Content

Related citations

Inhibition of complement C5a prevents breakdown of the blood-brain barrier and pituitary dysfunction in experimental sepsis. [Crit Care. 2009]
Inhibition of complement C5a prevents breakdown of the blood-brain barrier and pituitary dysfunction in experimental sepsis.
Flierl MA, Stahel PF, Rittirsch D, Huber-Lang M, Niederbichler AD, Hoesel LM, Touban BM, Morgan SJ, Smith WR, Ward PA, et al. Crit Care. 2009; 13(1):R12. Epub 2009 Feb 6.
Review Sepsis-associated delirium. [Intensive Care Med. 2007]
Review Sepsis-associated delirium.
Ebersoldt M, Sharshar T, Annane D. Intensive Care Med. 2007 Jun; 33(6):941-50. Epub 2007 Apr 5.
Regulation by C5a of neutrophil activation during sepsis. [Immunity. 2003]
Regulation by C5a of neutrophil activation during sepsis.
Riedemann NC, Guo RF, Bernacki KD, Reuben JS, Laudes IJ, Neff TA, Gao H, Speyer C, Sarma VJ, Zetoune FS, et al. Immunity. 2003 Aug; 19(2):193-202.
Review C5a, a therapeutic target in sepsis. [Recent Pat Antiinfect Drug Discov. 2006]
Review C5a, a therapeutic target in sepsis.
Guo RF, Ward PA. Recent Pat Antiinfect Drug Discov. 2006 Jan; 1(1):57-65.
Anti-complement strategies in experimental sepsis. [Scand J Infect Dis. 2003]
Anti-complement strategies in experimental sepsis.
Ward PA, Riedemann NC, Guo RF, Huber-Lang M, Sarma JV, Zetoune FS. Scand J Infect Dis. 2003; 35(9):601-3.

See reviews... See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Free in PMC
Free full text articles in PMC

Recent activity

Clear Turn Off Turn On

Sepsis-associated delirium: the pro and con of C5a blockade.
Sepsis-associated delirium: the pro and con of C5a blockade.
Crit Care. 2009 ;13(2):135. Epub 2009 Apr 22 .

PubMed
Year in review 2008: Critical Care--cardiology.
Year in review 2008: Critical Care--cardiology.
Crit Care. 2009 ;13(5):229. Epub 2009 Oct 21 .

PubMed
Fat tissue and adiponectin: new players in critical care?
Fat tissue and adiponectin: new players in critical care?
Crit Care. 2009 ;13(4):174. Epub 2009 Aug 5 .

PubMed
Examining appropriate diagnosis and treatment of malaria: availability and use o...
Examining appropriate diagnosis and treatment of malaria: availability and use of rapid diagnostic tests and artemisinin-based combination therapy in public and private health facilities in south east Nigeria.
BMC Public Health. 2010 Aug 16 ;10:486.

PubMed
Coerced addiction treatment: Client perspectives and the implications of their n...
Coerced addiction treatment: Client perspectives and the implications of their neglect.
Harm Reduct J. 2010 Jun 20 ;7:13.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to: